Gregory JEDD, Ph.D, Senior Principal Investigator

Gregory Jedd earned his bachelors degree in biology at the Foothill Community College and Stanford University. He received his PhD from the University of Chicago and did his postdoctoral work in Nam-Hai Chua’s lab at the Rockefeller University where he began to develop Neurospora crassa as a model system for cellular biology.  In September of 2004 he moved to Singapore to establish an independent research group.

You may wish to contact Dr Gregory JEDD at:

Tel: (65) 6872 7000 ,  6872 7708  or  6872 7709  (DID) Email: gregory@tll.org.sg  

For information on PhD studies at TLL, click HERE

Overview

The broad goal of our lab is to understand the fundamental mechanisms that govern cell growth and differentiation. We work on a variety of topics, ranging from organelle biogenesis and membrane protein targeting, to the systems biology of multicellular fungi. These diverse projects are unified by the view that all cellular processes are self-organized and governed by fundamental and recurring principles, which we strive to elucidate. For much of our work, we use the genetically amenable filamentous fungus, Neurospora crassa, as a model organism, and employ a multidisciplinary approach that combines the power of haploid genetics with molecular genetic, biochemical, microscopic, and computational methods. One long-term goal of the lab is to use the design principles learned from these studies to engineer synthetic organelles with applications in nanotechnology and bioengineering.

Topics of research

I. Organelle biogenesis

Eukaryotic cells possess a diverse set of membranous organelles that compartmentalize functions essential for cell growth, metabolism, and development. Each class of organelle depends on a distinct suite of resident proteins for the execution of specialized function. We are addressing questions relating to the basic mechanisms that determine the composition, activity and abundance of organelles. We are also keen to understand how organelles evolve to support evolutionary radiation.

II. Membrane protein biogenesis

Membranous compartments retain their identity and proliferate through continuous protein synthesis and organelle-specific targeting. Many membrane proteins are synthesized on free cytosolic ribosomes and need to be actively targeted to their compartment of residence. We are using a multidisciplinary approach to determine how these proteins are recognized and integrated to the appropriate membrane. A major goal of this work is to use purified components to reconstitute these pathways in cell-free systems.

III. Compartmentation through aggregation

We have identified a new class of low complexity proteins that compartmentalize fungal cells though aggregation. We are currently working to understand how this aggregation is controlled and its potential relevance to human cell biology and disease.

IV. Multicellular organization

Most of the fungi are based on cellular filaments composed of interconnected compartments, and these provide the basis for fungal multicellular organization. We use the fungi as model systems for understanding the basis of multicellular development.  Specifically, we would like to learn how the activities of individual compartments are coupled and coordinated to produce organism-level structure and behavior.