Publications

Prasad, R., S. Kawaguchi, and D.T.W. Ng. 2010. A Nucleus-based Quality Control Mechanism for Cytosolic Proteins. Molecular Biology of the Cell 21: 2117–2127.

Wang, S., and D.T.W. Ng. 2010. Evasion of Endoplasmic Reticulum Surveillance Makes Wsc1p an Obligate Substrate of Golgi Quality Control. Molecular Biology of the Cell 21: 1153–1165.

Kanehara, K., W. Xie, and D. T. W. Ng. 2010. Modularity of the Hrd1 ERAD complex underlies its diverse client range. The Journal of Cell Biology 188: 707-716.

Ng, D. T. W., E. D. Spear, and P. Walter.  2000. The unfolded protein response pathway regulates
multiple aspects of secretory and membrane protein biogenesis and endoplamic reticulum quality control.  J. Cell Biol.  150:77-88.

Spear, E. D. and D. T. W. Ng.  2001.  The unfolded protein response: no longer just a special teams player.  Traffic.  2:515-523.

Ng, D. T. W.  2001. Interorganellar signal transduction: The arrest of secretion response.  Dev. Cell.  1:319-320.

Vashist, S., W. Kim, W. Belden, E. D. Spear, C. Barlowe, and D. T. W. Ng.  2001.  Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding.  J. Cell Biol.  155:355-367.

Helenius, J., D. T.W. Ng, C. L. Marolda, P. Walter, M. A. Valvano and M. Aebi.  2002.  The RFT1 protein is required for the translocation of lipid-linked oligosaccharides across the membrane of the endoplasmic reticulum.  Nature.  415:447-450.

Vashist, S., C. G. Frank, C. A. Jakob, and D.T.W. Ng. 2002. Two Distinctly Localized P-Type ATPases Collaborate to Maintain Organelle Homeostasis Required for Glycoprotein Processing and Quality Control. Mol. Biol. Cell. 13:3955-3966.

Spear, E. D. and D. T. W. Ng. 2003. Stress tolerance of misfolded carboxypeptidase Y requires maintenance of protein trafficking and degradation pathways. Mol. Biol. Cell. 14:2756-2767.

Vashist and D. T. W. Ng. 2004. Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control. J. Cell Biol. 165:41-42.

Ng, D. T. W. 2004. Heat/Stress Responses. In Encyclopedia of Biological Chemistry. 2:343-347. Elsevier Inc., San Diego, CA.

Ng, D. T. W. 2005. Screening for mutants defective in secretory protein maturation and ER quality control. Methods. 35:366-372.

Sayeed, A. and D. T. W. Ng. 2005. Search and Destroy: ER quality control and ER-associated degradation. In Critical Reviews in Biochemistry and Molecular Biology. 40:1-16. Taylor and Francis, Inc. London, UK.

Spear, E. D. and D. T. W. Ng. 2005. Single, context-specific glycans can target misfolded glycoproteins for ER-associated degradation. J. Cell Biol. 169:73-82.

Kim, W., E. D. Spear, and D. T. W. Ng. 2005. Yos9p detects and targets misfolded glycoproteins for ER-associated degradation. Mol. Cell. 19:753-764.

Ismail, N. and D. T. W. Ng. 2006. Have you HRD? Understanding ERAD Is DOAble! Cell. 126:237-239.

Xie, W., K. Kanehara, A. Sayeed and D.T.W Ng. 2009. Intrinsic Conformational Determinants Signal Protein Misfolding to the Hrd1/Htm1 Endoplasmic Reticulum–associated Degradation System. Molecular Biology of the Cell. 20:3317–3329.