Publications

Ng, D. T. W., E. D. Spear, and P. Walter.  2000. The unfolded protein response pathway regulates multiple aspects of secretory and membrane protein biogenesis and endoplamic reticulum quality control.  J. Cell Biol.  150:77-88.

Spear, E. D. and D. T. W. Ng.  2001.  The unfolded protein response: no longer just a special teams player.  Traffic.  2:515-523.

Ng, D. T. W.  2001. Interorganellar signal transduction: The arrest of secretion response.  Dev. Cell.  1:319-320.

Vashist, S., W. Kim, W. Belden, E. D. Spear, C. Barlowe, and D. T. W. Ng.  2001.  Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding.  J. Cell Biol.  155:355-367.

Helenius, J., D. T.W. Ng, C. L. Marolda, P. Walter, M. A. Valvano and M. Aebi.  2002.  The RFT1 protein is required for the translocation of lipid-linked oligosaccharides across the membrane of the endoplasmic reticulum.  Nature.  415:447-450.

Vashist, S., C. G. Frank, C. A. Jakob, and D.T.W. Ng. 2002. Two Distinctly Localized P-Type ATPases Collaborate to Maintain Organelle Homeostasis Required for Glycoprotein Processing and Quality Control. Mol. Biol. Cell. 13:3955-3966.

Spear, E. D. and D. T. W. Ng. 2003. Stress tolerance of misfolded carboxypeptidase Y requires maintenance of protein trafficking and degradation pathways. Mol. Biol. Cell. 14:2756-2767.

Vashist and D. T. W. Ng. 2004. Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control. J. Cell Biol. 165:41-42.

Ng, D. T. W. 2004. Heat/Stress Responses. In Encyclopedia of Biological Chemistry. 2:343-347. Elsevier Inc., San Diego, CA.

Ng, D. T. W. 2005. Screening for mutants defective in secretory protein maturation and ER quality control. Methods. 35:366-372.

Sayeed, A. and D. T. W. Ng. 2005. Search and Destroy: ER quality control and ER-associated degradation. In Critical Reviews in Biochemistry and Molecular Biology. 40:1-16. Taylor and Francis, Inc. London, UK.

Spear, E. D. and D. T. W. Ng. 2005. Single, context-specific glycans can target misfolded glycoproteins for ER-associated degradation. J. Cell Biol. 169:73-82.

Kim, W., E. D. Spear, and D. T. W. Ng. 2005. Yos9p detects and targets misfolded glycoproteins for ER-associated degradation. Mol. Cell. 19:753-764.

Ismail, N. and D. T. W. Ng. 2006. Have you HRD? Understanding ERAD Is DOAble! Cell. 126:237-239.