Our laboratory uses integrative approaches to elucidate epigenetic and transcriptional mechanisms that underlie the transition from healthy to pathological states of Alzheimer’s disease (AD) during aging. Through detailed analyses of publicly available human aging and AD datasets, we found that alteration in intron retention patterns is a key feature that is linked to aging across different species and AD (Adusumalli et al., 2019. PMID: 30868713). We are now trying to establish if intron retention of specific genes may cause the pathogenesis of healthy cells using iPSCs-induced human neurons as a model system. In addition, we used Drosophila and mouse embryonic stem cells as model systems to uncover new mechanisms that can regulate different aspects of development and aging. For instance, we found that phosphorylation of (i) nuclear architectural protein may regulate the locomotor activity of Drosophila (Ong & Lin, 2018. PMID: 29571672) and (ii) TET enzymes may be important for robust activation of neuronal genes during differentiation (Rao et al., under revision).
We are seeking a highly motivated Postdoctoral Fellow to work on some of the interesting findings made from our current studies. Successful applicant will use mouse and iPSCs-induced human neurons as model systems to study the effect of epigenetic changes on AD progression.
- PhD Degree in Biology, Biochemistry, or related field from a reputable university
- At least one first-author research paper in an international peer-reviewed journal
- Research experience in at least two of the following areas: Tissue culture (including stem cells expertise), molecular techniques (e.g. protein biochemistry, microscopy) and/or genomic approaches (e.g. ChIP-seq)
- Advanced bioinformatics skills will be an advantage
Salary and benefits are commensurable to educational qualifications and working experience of the candidate. Benefits include annual leave, medical and flexi-benefits, etc.
Interested individuals should send their applications (including a cover letter, curriculum vitae, and three referees’ contacts/ recommendation letters) to:
Dr ONG Chin Tong
Temasek Life Sciences Laboratory Ltd
(Please note that only shortlisted candidates will be notified)